Rejuran vs Profhilo for Men: 2026 Bangkok Guide

Men walk into the clinic with a fairly consistent complaint. The skin looks tired. There is a dull, slightly rough quality across the cheeks, some crepiness starting under the eyes, maybe old acne scarring on the jawline that never fully settled, and a general sense that the face does not bounce back the way it did at thirty. Botox and fillers do not fix any of that, because those treatments freeze movement or add volume. What these men are actually describing is a loss of skin quality, and that is the specific problem Rejuran and Profhilo were built to address.

Both are injectables. Both improve the skin from the inside rather than sitting on top of it like a cream. But they are not interchangeable, and a lot of online comparisons blur them into the same thing. Rejuran is a regenerative repair treatment based on polynucleotides, the long DNA-derived chains extracted from salmon. Profhilo is a bio-remodeling treatment built around an unusually high concentration of stabilized hyaluronic acid. They overlap in the sense that both improve elasticity and texture over time, but they get there by different biological routes, on different timelines, with different session counts and different price tags.

This guide compares the two head to head, with a male skin angle, transparent Bangkok pricing in THB and USD, an honest account of who is not a good candidate, the recovery you should actually expect, and the risks worth knowing. Everything here is educational. Both treatments are prescription medical procedures that require an in-person consultation with a qualified doctor, who will assess your skin and medical history before recommending anything.

Why men's skin is a different starting point

Male skin is not just female skin with stubble on it. On average it is roughly 20-25% thicker because of higher dermal collagen density, and it tends to be oilier thanks to larger, more active sebaceous glands driven by testosterone. That sounds like an advantage, and in your twenties it is. The downside shows up later. Men accumulate more cumulative sun exposure (less daily sunscreen, more outdoor work and sport), shave constantly which stresses the skin barrier, and present for cosmetic care years later than women do, often when photodamage and laxity are already established.

The practical consequence is that regenerative treatments which work on the deeper dermis, where collagen and elastin live, tend to suit the male face well. There is more tissue to remodel and the results read as healthier skin rather than anything obviously cosmetic, which is what most men want. Neither Rejuran nor Profhilo adds volume or changes your bone structure or expression. They improve the quality of the skin itself, which is precisely why they have become two of the more requested skin treatments among men in Bangkok. If you want the broader picture of regenerative options, see our overview of Rejuran for men.

What is Rejuran?

Rejuran is a brand of injectable polynucleotide (PN) treatment originally developed in South Korea. The active ingredient is a purified fraction of polynucleotides extracted from salmon DNA, specifically the sperm or gonadal tissue of salmon and salmon trout. Before you wince at that, the source material is highly refined: the proteins that would normally trigger a fish allergy are removed during manufacturing, leaving the DNA-derived polymer chains.

Polynucleotides and the closely related polydeoxyribonucleotide (PDRN) work in a way that genuinely is regenerative rather than just cosmetic. According to a 2025 comparative review in *Pharmaceutics*, these molecules selectively activate the adenosine A2A receptor, which dampens inflammation, promotes angiogenesis (new small blood vessels), and stimulates fibroblasts, the cells that manufacture collagen and elastin. The same review notes they enhance production of collagen types I and III, the structural proteins that give skin its firmness and resilience (Kim, *Pharmaceutics*, 2025). In plainer terms, Rejuran does not fill a line; it nudges the skin to repair and rebuild itself.

That mechanism makes Rejuran a good fit for men who want:

• Repair of sun damage, dullness and rough texture

• Improvement of fine lines and early crepey skin, especially under the eyes

• Help with the appearance of old acne scarring and enlarged pores

• A genuine rebuilding of skin resilience rather than a surface effect

Rejuran is also sold in a few variants tuned to different concerns. Rejuran (sometimes labelled Healer) is the standard formulation for overall skin quality and texture. Rejuran I is a lighter, thinner formulation designed for the delicate under-eye area. Rejuran S is more concentrated and aimed at scars. Rejuran HB combines polynucleotides with hyaluronic acid for an added hydration boost. Which one suits you is a clinical decision, not a menu choice, and a good injector will match the variant to your skin rather than upselling the priciest option.

Rejuran evidence and results

A 2025 systematic review in the *Journal of Cosmetic Dermatology* pooled the available studies on polynucleotides in aesthetic medicine. It found statistically significant improvements in wrinkles, skin texture, elasticity and hydration, with one included study reporting a 95.7% improvement in crow's-feet wrinkles twelve weeks after treatment. Importantly, none of the included studies reported severe adverse events; the side effects were mild and short-lived, such as localized swelling, redness or itching that typically settled within a week (Lampridou et al., 2025).

The honest caveat the same review makes is that the overall quality of the evidence is still low to moderate, and standardized protocols are not fully established. Rejuran works, the data is encouraging, but it is not the deep, decades-long evidence base of something like a basic hyaluronic acid filler. Set expectations accordingly: this is gradual, cumulative skin improvement, not a dramatic overnight change.

In practice, results build over about one to three months as new collagen forms, and a completed course tends to last in the region of six to twelve months before maintenance is considered. Most protocols use three to four sessions spaced two to four weeks apart to start.

What is Profhilo?

Profhilo is an injectable made of stabilized hyaluronic acid (HA), the same water-binding sugar molecule your body already produces in skin, joints and connective tissue. What sets it apart from a standard HA filler is both the dose and the way it behaves. Each treatment delivers 64 mg of HA in 2 mL, split between high-molecular-weight and low-molecular-weight chains bound together through a patented thermal process (no chemical cross-linking agents). A systematic review in *Plastic and Aesthetic Nursing* confirms this 32 mg high-weight plus 32 mg low-weight composition (Sparavigna et al., 2026).

Because it is not stiffly cross-linked, Profhilo does not stay put as a bump to add volume the way a cheek or jaw filler does. Instead it spreads through the tissue and acts as what is called a bio-remodeler. The high-weight HA pulls in water for immediate hydration, while the low-weight HA signals fibroblasts to step up production of collagen and elastin. The result is skin that looks better hydrated, firmer and tighter, without any change to your facial proportions.

That makes Profhilo a strong choice for men who want:

• Deep hydration and a healthier glow in dull, dehydrated skin

• Subtle firming and tightening of mild skin laxity on the face or neck

• A natural-looking improvement with no added volume and no frozen look

• A shorter course, since the standard protocol is just two sessions

Profhilo evidence and results

The same 2026 systematic review concluded that Profhilo treatment can improve skin laxity, hydration, elasticity and density while reducing wrinkles and volume loss, across the face and other areas. The recommended protocol is two sessions 30 days apart, with optional maintenance roughly every two months thereafter. Reported side effects were mild and expected, mainly bruising, swelling and small temporary bumps at the injection points that usually resolve within about 72 hours, with no serious adverse events (Sparavigna et al., 2026).

A separate worldwide post-marketing safety analysis reviewed 42,394 patient exposures over three years and documented only 12 adverse event reports, all of which resolved without complication, attributing most reactions to injection technique rather than the product itself (Cassuto et al., 2020). For a treatment used on this scale, that is a reassuring profile.

Profhilo tends to show visible results faster than Rejuran, often within one to two weeks of the first session and more clearly after the second, with effects generally lasting six to twelve months.

Rejuran vs Profhilo: the core comparison

The short version: if the chief complaint is damaged, textured, scarred or aging skin that needs rebuilding, Rejuran is usually the lead. If the chief complaint is dry, dull, slightly lax skin that needs hydration and a firmness reset, Profhilo is usually the lead. Worth noting on the safety side: because Profhilo is hyaluronic acid, it can be dissolved with the enzyme hyaluronidase in the rare event of a problem, whereas Rejuran cannot be reversed once injected. Plenty of men benefit from both, and many Bangkok clinics, including Menscape, sequence them. For more on the wider category of injectable hydration treatments, see our guide to Profhilo vs skin boosters, and for the deeper science on the regenerative side, our polynucleotides vs Rejuran explainer.

Bangkok pricing in THB and USD

Pricing varies by clinic, by the specific Rejuran variant, by how many cc are used and by who is injecting. The ranges below reflect mainstream Bangkok aesthetic clinic pricing in 2026 and are indicative only. Always confirm the exact figure at consultation, since it depends on your treatment plan.

USD conversions use an approximate rate near THB 36 to USD 1 and will move with the exchange rate. The Western comparison figures are typical clinic course prices in major US and UK cities and are indicative only; UK two-session Profhilo courses commonly land around USD 900-1,500, with US pricing running higher, and a Rejuran course in either market commonly exceeds USD 3,000. Bangkok's lower pricing is not a quality compromise; it reflects lower clinic operating costs and a highly competitive local aesthetics market, which is a large part of why medical tourism for skin treatments has grown here.

What actually drives the cost

• Number of sessions. Rejuran's three-to-four-session course is the single biggest cost difference versus Profhilo's two.

• Product variant and volume. Rejuran S or HB, or a larger cc volume to cover the full face plus neck, costs more than a standard single-area treatment.

• Genuine product and traceability. Authentic, properly stored Rejuran and Profhilo cost the clinic more than grey-market stock. This is not where to bargain-hunt.

• Who injects. A doctor experienced in male facial treatment commands a higher fee than a junior injector, and that experience matters for both safety and results.

• Add-ons. Numbing, combination with other boosters, or bundling with treatments like skin boosters changes the total.

Who is a good candidate, and who is not

These treatments suit a wide range of men, but they are not for everyone, and a responsible clinic will turn some people away. You are likely a reasonable candidate if you are a generally healthy adult bothered by skin quality (texture, dullness, fine lines, mild laxity, old acne scarring) and you have realistic expectations of gradual, natural improvement rather than a dramatic transformation.

You should not proceed, or should at minimum have a careful pre-treatment discussion, in these situations:

• Active skin infection, acne flare or inflammation at the injection site. Treatment should wait until the area is calm.

• Pregnancy or breastfeeding. There is no adequate safety data for either treatment in pregnancy, so both are deferred as a precaution.

• Known severe fish or seafood allergy (Rejuran specifically). Although purification removes most allergenic protein, a significant salmon or fish allergy is a reason for caution and an explicit conversation with your doctor; Profhilo, being hyaluronic acid, may be the safer alternative here.

• Active autoimmune disease in flare, or immunosuppressive therapy. Coordinate with your specialist before any regenerative injectable.

• Bleeding disorders or blood-thinning medication. This raises bruising risk and needs to be reviewed.

• A history of keloid or hypertrophic scarring, which warrants caution with any needling procedure.

• Recent or planned dental work or other facial procedures, which may need to be timed around treatment.

This is exactly why both are prescription treatments. The contraindication list is not a formality; it is the reason an in-person medical assessment is non-negotiable before either injection.

What the procedure and recovery actually look like

Both treatments follow a broadly similar process, and both are genuine lunch-break procedures for most men, though Rejuran can leave brief visible bumps.

Step by step:

1. Consultation and assessment. The doctor reviews your skin, goals and medical history, confirms you are a candidate, and decides between Rejuran (and which variant) or Profhilo, or a sequenced plan.

2. Cleansing and numbing. The area is cleaned and a topical anesthetic cream is applied for around 20-30 minutes to reduce discomfort.

3. Injection. Using a fine needle, the product is placed in a series of small injections across the treatment area. Profhilo classically uses a small number of defined points (the so-called BAP technique on the face); Rejuran is distributed in a finer grid of micro-injections.

4. Aftercare briefing. The session itself usually takes 15-30 minutes. You are given aftercare instructions before you leave.

Staged recovery:

• First 24-48 hours. Expect small bumps or papules at the injection points, more noticeable with Rejuran, along with possible mild redness, swelling or pinpoint bruising. This is normal and settles. Avoid touching or massaging the area unless told otherwise, and skip makeup for the rest of the day.

• Days 2-3. Most visible bumps and redness subside. Profhilo's small product mounds typically flatten within about 72 hours as the HA spreads.

• First week. Avoid intense exercise, saunas, steam rooms, very hot showers, alcohol and direct strong sun for roughly 24-48 hours, and ease back in over the week. Use sunscreen.

• Weeks 2-12. Profhilo results become visible within the first one to two weeks. Rejuran's collagen-driven improvement builds more gradually over one to three months as the course is completed.

The practical aftercare advice that matters most: do not book either treatment the day before a wedding, photo shoot or major event. Leave a comfortable buffer in case of bruising.

Risks and side effects

For both treatments the common side effects are mild, local and temporary: redness, swelling, bruising, tenderness and small bumps at the injection sites. As noted above, the polynucleotide review found no severe adverse events and described side effects that generally resolved within a week, and the Profhilo data showed reactions that were mild and typically resolved in around 72 hours.

The more serious risks are rare and overwhelmingly relate to injection technique rather than the products themselves. The most important is vascular occlusion, where filler material inadvertently blocks or compresses a blood vessel. A safety review of hyaluronic acid fillers put the incidence at roughly 3 per 1,000 injections and stressed that thorough anatomical knowledge and proper technique are the key defenses (Rohrich et al., 2019). Profhilo's spreading, low-cohesivity behavior makes this less of a concern than with volumizing fillers, and because it is hyaluronic acid it can be dissolved with hyaluronidase if a vascular issue does occur, an option that is not available with Rejuran. Even so, the principle holds for any facial injection: the injector's training is your main safety margin.

Seek urgent medical care if, after either treatment, you develop any of the following, which can signal vascular compromise or infection:

• Severe or escalating pain that is out of proportion to a normal injection

• Skin that turns dusky, white, blotchy or mottled, or develops a net-like discoloration

• Vision changes of any kind, which is a medical emergency

• Spreading redness, heat, swelling, fever or pus, suggesting infection

• Skin that blisters, breaks down or starts to ulcerate

These outcomes are uncommon, but knowing the warning signs and contacting your clinic immediately makes a genuine difference.

Choosing a safe clinic in Bangkok

Bangkok has excellent aesthetic clinics and also some you should avoid. The treatment is only as good as the person holding the needle and the authenticity of the product, so vet both.

Look for:

• A licensed doctor performing the injections, ideally one with specific experience treating men's faces, not a technician in a salon.

• Genuine, traceable product. Ask to see the sealed Rejuran or Profhilo packaging and lot number. Reputable clinics are happy to show it.

• A real consultation that takes a medical history and discusses your candidacy and contraindications, rather than booking you straight onto the table.

• A clean, properly equipped medical facility with clear aftercare support and a way to reach a doctor if something goes wrong.

• Transparent pricing with no pressure to upgrade to the most expensive variant without a clinical reason.

Red flags worth walking away from: prices that look too good to be true (a likely sign of counterfeit or grey-market product), no doctor on site, refusal to show product packaging, treatment offered in a non-medical setting like a beauty salon or spa, and aggressive upselling. As Cleveland Clinic bluntly advises about injectables in general, you should not get these treatments from a beauty salon or spa.

So which one should you choose?

If you take one decision rule away, make it this. Choose Rejuran when the dominant issue is the condition of the skin itself: rough texture, photodamage, fine lines, enlarged pores or old acne scarring that you want to genuinely repair and rebuild over a course of treatments. Choose Profhilo when the dominant issue is hydration and firmness: dull, dry, slightly lax skin that needs a quicker glow-and-tighten reset in just two sessions. If your main concern is sagging rather than texture or hydration, it is worth reading our wider rundown of skin tightening for men before you decide, and if you are weighing regenerative options more broadly, our exosomes vs PRP comparison covers the adjacent cell-signaling treatments.

A large share of men do not have to pick one. Because the mechanisms are complementary, sequencing Rejuran for repair and Profhilo for hydration is a common and effective combination, and it is one of the most requested regenerative plans among male patients in Bangkok. The right answer for your face depends on your skin, your goals and your medical history, which is what a consultation is for.

Both Rejuran and Profhilo are prescription medical treatments that require an in-person consultation and a doctor's assessment before they can be recommended or performed. Nothing in this article is a substitute for that.

If you want a clear, no-pressure plan, book a consultation at Menscape and a doctor will assess your skin and tell you honestly whether Rejuran, Profhilo, both, or neither is the right move for you.

Frequently Asked Questions

Can I combine Rejuran and Profhilo?

Yes, and many men do. The two treatments are complementary: Rejuran repairs and regenerates the skin while Profhilo hydrates and firms it. A common approach is to sequence them rather than inject both on the same day, and your doctor will plan the timing and order based on your skin and priorities. A consultation is needed to confirm a combined plan suits you.

Which one works faster, Rejuran or Profhilo?

Profhilo usually shows visible results faster, often within one to two weeks of the first session because of its immediate hydrating effect. Rejuran works more gradually, with collagen-driven improvement building over roughly one to three months as you complete the course. Neither is an overnight treatment in the sense of a dramatic same-day change.

Which is better for acne scars and rough texture?

Rejuran is generally the stronger choice for old acne scarring, photodamage and rough texture, because polynucleotides stimulate genuine tissue repair and collagen formation. There is even a more concentrated variant, Rejuran S, aimed specifically at scarring. Profhilo is more about hydration and firmness than scar remodeling. A doctor should assess your scars to confirm the best option.

How many sessions will I need and how often?

Rejuran typically starts with three to four sessions spaced two to four weeks apart, then maintenance later. Profhilo uses a standard two-session protocol 30 days apart, with optional maintenance roughly every two months. Results from both last in the region of six to twelve months before a top-up is considered.

Is Rejuran safe if I have a fish or seafood allergy?

Caution is needed. Rejuran's polynucleotides are derived from salmon DNA, and although purification removes most of the allergenic protein, a significant fish or seafood allergy is a reason to flag it explicitly with your doctor before treatment. In that situation Profhilo, which is hyaluronic acid rather than fish-derived, may be a safer alternative. This is exactly the kind of thing the pre-treatment medical assessment exists to catch.

Do these treatments change how my face looks or freeze my expression?

No. Neither Rejuran nor Profhilo adds volume or alters your bone structure, and neither affects muscle movement the way Botox does. They improve the quality of the skin itself, so results read as healthier, fresher skin rather than an obviously cosmetic change, which is what most men are after.

Can Rejuran or Profhilo be dissolved if I am unhappy with the result?

This is one real difference between them. Profhilo is hyaluronic acid, so in the rare event of a problem it can be broken down quickly with the enzyme hyaluronidase, and otherwise it is metabolized naturally over months. Rejuran is a regenerative polynucleotide treatment, not a filler, so it cannot be dissolved; its effects simply fade over time. Neither adds volume, so a dramatic over-correction is unlikely with either, but the reversibility of Profhilo is a genuine safety point worth knowing.

How much do Rejuran and Profhilo cost in Bangkok?

As an indicative 2026 guide, Rejuran runs roughly THB 12,000-22,000 per session, with a full three-to-four-session course around THB 36,000-80,000. Profhilo is roughly THB 15,000-25,000 per session, with the standard two-session course around THB 30,000-50,000. Final pricing depends on the product variant, the volume used and the clinic, so confirm at consultation. Both are typically 50-65% cheaper than equivalent courses in the US or UK.

Is there any downtime?

Minimal for most men. Expect small bumps at the injection points for about 24-48 hours (more noticeable with Rejuran), along with possible mild redness, swelling or pinpoint bruising that settles within a day or two. Both are realistic lunch-break treatments, but it is sensible to avoid a major event for a few days afterward in case of bruising, and to skip intense exercise, saunas and alcohol for the first day or two.

When should I seek urgent care after treatment?

Serious problems are rare, but contact your clinic or seek urgent medical care immediately if you develop severe or escalating pain, skin that turns white, dusky, blotchy or mottled, any change in vision, or spreading redness, heat, swelling, fever or pus. These can signal vascular compromise or infection and need prompt attention. Ordinary mild swelling, redness and small bumps are expected and not a cause for alarm.

References

• Lampridou et al., The Effectiveness of Polynucleotides in Esthetic Medicine: A Systematic Review, Journal of Cosmetic Dermatology, 2025 (PMC11845969)

• Kim ST, Comparison of Polynucleotide and Polydeoxyribonucleotide in Dermatology: Molecular Mechanisms and Clinical Perspectives, Pharmaceutics, 2025 (PMC12388916)

• Sparavigna et al., A Systematic Review of the Efficacy and Safety of Profhilo and Profhilo Body, Plastic and Aesthetic Nursing, 2026 (PMC13038071)

• Cassuto et al., Safety Assessment of High- and Low-Molecular-Weight Hyaluronans (Profhilo) from Worldwide Postmarketing Data, BioMed Research International, 2020 (PMC7327616)

• Rohrich et al., Practical Approach and Safety of Hyaluronic Acid Fillers, Plastic and Reconstructive Surgery Global Open, 2019 (PMC6635180)

• Cleveland Clinic, Lip Fillers: What to Expect, Types, Benefits and Side Effects (patient guidance on HA injectables)