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Most men do not think about skin treatments until something specific bothers them: a tired, dull look that no amount of sleep fixes, fine lines around the eyes that show up in photos, or acne scars and rough texture that have lingered for years. Men's skin is generally thicker and oilier than women's, and it takes a daily beating from sun, shaving, pollution, and stress. Rejuran, often called the "skin healer," is an injectable treatment built for exactly this kind of repair from within, and in Bangkok it has become one of the most requested regenerative skin treatments for men who want a healthier look without changing the shape of their face.
This guide explains what Rejuran actually is, how polynucleotides work, who is and is not a good candidate, what the procedure and recovery feel like, realistic Bangkok pricing in THB and USD, how it compares to other injectables, and the results you can reasonably expect. It is written for men, with the male skin angle in mind throughout.
What Is Rejuran?
Rejuran is a brand name. The active ingredient is a group of molecules called polynucleotides (PNs), which are short, highly purified fragments of DNA. Think of them as cellular building-block molecules that signal your skin to repair and renew itself. In Rejuran and similar products, these polynucleotides are extracted and purified from salmon or trout DNA, then filtered to a high grade so that almost no fish protein remains.
A closely related molecule you will see mentioned is PDRN (polydeoxyribonucleotide), which is essentially the same family of DNA-derived ingredient. Reviews of the science describe how this class of molecule promotes fibroblast activity (fibroblasts are the cells that make collagen), supports collagen production and new blood-vessel formation, and calms inflammation in the skin (Oh et al., Biomaterials Research, 2025). The same review notes the source material is refined from trout or chum salmon, which is why fish allergy matters for screening.
It helps to be clear about what Rejuran is not. It is not a dermal filler and it does not add volume or reshape your jaw, cheeks, or chin. It is not Botox and does not freeze muscles. Instead, it improves the *quality* of the skin itself: how hydrated, smooth, firm, and resilient it is.
How It Works in Plain Terms
When injected into the upper layers of the skin, the polynucleotides do a few things:
Support collagen and elastin. Collagen keeps skin firm; elastin lets it bounce back. Both decline with age and sun exposure.
Improve hydration. The molecules help the skin hold water, which is part of why skin can look plumper and less dull.
Calm and repair. They have a soothing, anti-inflammatory effect that supports healing of damaged skin, including some types of scarring.
Build resilience over time. Because the effect is regenerative rather than a quick fill, improvements accumulate across a course of sessions.
Benefits of Rejuran for Men
Goal | What Rejuran targets | Why it suits men |
Tired, dull skin | Hydration and glow from within | Counters the flat, washed-out look from stress and screen time |
Fine lines | Crow's feet and forehead lines | Softens lines without freezing expression |
Texture and pores | Roughness and uneven surface | Helps oilier, thicker male skin look smoother |
Acne scarring | Skin repair and remodeling | Useful for the textured scarring many men carry from teen acne |
Firmness and elasticity | Collagen and elastin support | Restores a springier feel as skin loses tone |
Natural result | Skin quality, not volume | No structural change, which most men prefer |
The appeal for men is that the result reads as "you look well," not "you had work done." There is no added volume and no obvious change to facial proportions.
Rejuran Product Variants
Rejuran is sold in a few formulations, and a good clinic will match the variant to your concern during the consultation. The exact lineup can vary by market, but the common types are:
Rejuran (Healer): the original, used for overall skin healing, texture, and fine lines across the face.
Rejuran S: a more concentrated version often used for targeted scarring and deeper lines.
Rejuran HB: blended with hyaluronic acid for an added hydration and plumping effect.
Rejuran i (eye): formulated for the thin, delicate skin under and around the eyes.
You do not need to memorize these. The point is that the treatment is tailored, and a man focused on acne scarring may receive a different plan from one focused mainly on under-eye crepiness.
Who Is a Good Candidate (and Who Is Not)
Rejuran may suit you if you:
Have dull, dehydrated, or rough-textured skin
Want to soften early fine lines without fillers or Botox
Have mild to moderate acne scarring or sun damage
Prefer a gradual, natural-looking improvement
Are in general good health and have realistic expectations
Rejuran is not appropriate, or needs careful medical review, if you:
Have a documented fish or salmon allergy. Because polynucleotides are derived from purified fish DNA, a true fish or salmon allergy is a genuine screening point, not a minor footnote. Tell your doctor before booking.
Are pregnant or breastfeeding. Safety data in these groups is limited, so treatment is generally deferred as a precaution.
Have an active skin infection, breakout, or inflammation at the injection sites.
Are prone to keloid or raised scarring.
Have a bleeding or clotting disorder, or take blood thinners, which raises bruising risk and should be discussed first.
A doctor-led, in-person medical assessment is required before any treatment so that these factors can be checked properly. This is not a walk-in retail procedure.
The Rejuran Procedure, Step by Step
A single session usually takes about 30 to 45 minutes start to finish.
Consultation and assessment. A doctor reviews your skin, your goals, your medical history, and any allergies or medications. The variant and number of sessions are agreed here.
Cleansing and numbing. The area is cleaned and a topical numbing cream is applied, usually for 20 to 30 minutes, to keep discomfort low.
Micro-injections. Using a fine needle, the doctor places many small injections across the target area. You may feel small pinches. Some men notice tiny raised bumps right after, which is normal and expected.
Aftercare and review. The skin is soothed, aftercare is explained, and any follow-up session is scheduled.
Pain and Comfort
Most men describe the sensation as mild, more "annoying than painful," thanks to the numbing cream. Thicker male skin can actually tolerate the micro-injections reasonably well. If you are needle-averse, say so at consultation so the team can pace the session.
Recovery and Results Timeline
Recovery is short and staged. Here is what to expect.
Day 1 to 2: Redness, mild swelling, and small bumps (often compared to mosquito bites) at injection points. Minor bruising is possible. Most of this settles within 24 to 48 hours.
Week 1 to 2: Bumps resolve, and skin starts to feel more hydrated and refreshed.
Month 1 to 3: The regenerative effects become visible. Texture, elasticity, and glow improve as collagen support builds. In clinical studies of polynucleotide injections for under-eye and crow's-feet wrinkles, the greatest improvement was typically seen around the 3-month mark after a short course of sessions (Ziade et al., Journal of Cosmetic Dermatology, 2026).
3 to 6 months: Continued remodeling, with results holding for several months before maintenance is considered.
Aftercare and Downtime Restrictions
To get the best result and lower the risk of irritation, for the first 24 to 48 hours you should generally:
Avoid makeup over the injection sites
Skip heavy exercise, saunas, steam rooms, and hot yoga
Avoid alcohol
Stay out of strong sun and use sunscreen once skin settles
Avoid rubbing, massaging, or picking at the treated area
Your clinic will give you specific instructions. Follow theirs over general advice.
Treatment Schedule
A typical course is 3 to 4 sessions spaced 3 to 4 weeks apart. Because the effect is regenerative and cumulative, a single session rarely delivers the full result. Many men then do a maintenance session once or twice a year to keep results topped up. Results are long-lasting, not permanent, and depend on completing the course and on which variant is used.
Quantified Results: What the Evidence Shows
It is worth being honest about the strength of the evidence, because that builds trust.
A systematic review of polynucleotides in aesthetic medicine pooled 9 studies covering 219 patients and found that PN injections showed promising results for reducing wrinkles and improving skin texture and elasticity, with only mild, transient side effects and no severe adverse events reported. The same review stressed that larger, higher-quality studies are still needed to confirm the best protocols (Lampridou et al., Journal of Cosmetic Dermatology, 2025).
A 2026 prospective study of 42 patients receiving polynucleotide injections for under-eye and crow's-feet wrinkles found statistically significant improvement in wrinkle scores at all time points, with the biggest gains at 3 months after two sessions, and only minor swelling or bruising that resolved without lasting problems (Ziade et al., 2026).
A 2025 multicenter study of a highly purified polynucleotide for dry, lined lips reported significant improvement in wrinkles and roughness, with side effects (brief swelling, mild pain, redness) that were mild and resolved the same day (Rho et al., Journal of Cosmetic Dermatology, 2025).
The takeaway is consistent: real, measurable improvements in skin quality, a favorable safety profile in the studies done so far, and a research field that is still maturing. Expect gradual improvement, not an overnight transformation.
Risks and Side Effects
For most men, Rejuran is well tolerated and side effects are mild and short-lived.
Common and expected (usually resolve in 1 to 2 days):
Redness and mild swelling
Small bumps at injection points
Mild bruising
Temporary tenderness
Less common:
Lingering bruising in those who bruise easily or take blood thinners
Small nodules that take longer to settle
Post-inflammatory pigmentation (temporary darkening at sites), which can be more noticeable in darker or tanned skin tones
Red-flag symptoms: contact your clinic or a doctor promptly if you notice:
Spreading redness, heat, or pain after the first couple of days
Pus or signs of infection
A bump that grows, hardens, or becomes painful instead of fading
Any sign of an allergic reaction such as hives, widespread swelling, or trouble breathing (seek emergency care)
These serious events are uncommon, but knowing the warning signs is part of being a sensible patient.
Have a question about your treatment?
Message our Bangkok clinic on WhatsApp and a doctor replies within minutes during clinic hours.
Choosing a Safe Clinic in Bangkok
Bangkok has excellent options, but quality varies. Use these checks.
Green flags:
A licensed doctor performs the assessment and the injections
The clinic asks about allergies (especially fish or salmon), medications, and pregnancy before booking
Genuine, brand-authentic Rejuran product with traceable packaging
Clear, written pricing and aftercare
A clean, medical-grade environment and proper consent process
Red flags:
Pressure to commit on the spot or "today only" pricing
No medical history taken and no allergy screening
Prices far below the market, which can signal counterfeit product
Injections by non-medical staff
No clear answer when you ask which Rejuran variant is being used
Costs of Rejuran in Bangkok (THB and USD)
Pricing depends on the clinic, the variant, and how many sessions you book. The figures below reflect typical Bangkok ranges. Prices are approximate and change over time, so confirm at consultation.
Option | Bangkok price (THB) | Bangkok price (USD)* | Typical US/UK price (USD)* |
Single session | 8,000 to 20,000 | ~220 to 550 | ~400 to 900 |
Full course (3 to 4 sessions) | 30,000 to 70,000 | ~820 to 1,900 | ~1,500 to 3,000+ |
Annual maintenance (1 to 2 sessions) | 8,000 to 35,000 | ~220 to 950 | ~400 to 1,800 |
*USD figures are approximate conversions for orientation only and depend on the exchange rate.
The savings angle: a full Bangkok course often lands in the range a single course of sessions might cost in the US or UK, which is a large part of why men traveling or living in Thailand choose to do regenerative skin work here. Ask what the package price includes, specifically the number of sessions, whether numbing and a follow-up review are covered, and whether maintenance is extra. As an aesthetic treatment, Rejuran is not covered by insurance.
How Rejuran Compares to Other Injectables
Rejuran is one tool among several. The right choice depends on your goal.
Treatment | What it does | Best for | Typical duration |
Rejuran (polynucleotides) | Repairs and regenerates skin quality | Dull, aging, scarred, or rough skin | Several months; course based |
Profhilo | Deep hydration plus collagen and elastin stimulation | Firmer, more elastic, bouncier skin | Around 6 months |
Skinboosters | Hydration and surface glow | Smoother texture and a fresh look | A few months |
Dermal fillers | Add volume and structure | A sharper jawline or chin definition | Often a year or more |
Botox | Relaxes muscles | Dynamic frown and forehead lines | A few months |
Which One Is Right for You?
Choose Rejuran if your main concern is overall skin *quality*, including texture, dullness, fine lines, and acne scarring, and you want repair from within with no volume change.
**Choose Profhilo or Skinboosters** if your priority is hydration and a quick, all-over glow and firmness boost.
**Choose dermal fillers** if you want to add structure, such as a stronger jawline or chin.
**Choose Botox** if your concern is expression lines from muscle movement.
Many men combine treatments. Rejuran is frequently paired with Botox or fillers in a staged plan so that skin quality, lines, and structure are each addressed with the right tool.
The Bottom Line for Men
Rejuran gives men a low-key, natural way to improve skin health: better texture, more hydration, softer fine lines, and help with scarring, without changing how your face is shaped. It works gradually over a course of sessions, has a reassuring safety record in the studies done so far, and is meaningfully more affordable in Bangkok than in the West. Because it is a medical injectable derived from purified fish DNA, it must be doctor-administered and requires an in-person consultation, including allergy and medical screening, before any treatment goes ahead.
Frequently Asked Questions
Is Rejuran painful for men?
Most men describe it as mild discomfort rather than real pain. A topical numbing cream is applied for 20 to 30 minutes first, which takes the edge off the micro-injections. Thicker male skin tends to tolerate the procedure reasonably well. Tell your clinic if you are sensitive to needles so they can pace the session.
How soon will I see results?
Skin often feels more hydrated and refreshed within 1 to 2 weeks. The deeper regenerative effects on texture, elasticity, and fine lines build over 1 to 3 months, with studies of polynucleotide injections typically showing the biggest improvement around the 3-month mark after a short course of sessions.
How many sessions do I need?
A typical plan is 3 to 4 sessions spaced 3 to 4 weeks apart. Because the effect is regenerative and cumulative, a single session rarely delivers the full result. Many men then do a maintenance session once or twice a year. Your doctor will tailor the number to your skin and goals.
Does Rejuran add volume like a filler?
No. Rejuran improves skin quality, texture, hydration, elasticity, and fine lines, rather than adding volume or reshaping your face. If you want structure, such as a sharper jawline or chin, that is a job for dermal fillers, which a doctor can discuss alongside Rejuran.
Can men with a fish or salmon allergy have Rejuran?
A documented fish or salmon allergy is an important screening point because polynucleotides are derived from purified fish DNA. The products are highly purified, but a true allergy must be discussed with the doctor before booking, and treatment may be avoided or handled with extra caution. Never skip mentioning it.
Is there any downtime?
Downtime is short. Expect redness, mild swelling, and small bumps that usually settle within 24 to 48 hours, with possible minor bruising. For the first day or two, avoid makeup over the sites, heavy exercise, saunas, alcohol, and strong sun, and do not rub the treated area.
How long do results last?
Results are long-lasting but not permanent. After completing the full course, improvements generally hold for several months before a maintenance session is considered. Longevity depends on completing the course, the Rejuran variant used, your skin, and your lifestyle, including sun protection.
Can Rejuran be combined with Botox or fillers?
Yes. Rejuran is often part of a staged plan with Botox for expression lines or fillers for structure, since each tool addresses a different concern. Rejuran handles skin quality, Botox handles muscle-driven lines, and fillers handle volume. Your doctor will sequence these safely.
Is Rejuran safe?
In the clinical studies done so far, polynucleotide injections have a favorable safety profile, with mostly mild, short-lived side effects such as redness, swelling, and small bumps, and no severe adverse events reported in a recent systematic review. That said, the research field is still maturing, and a proper medical assessment is essential to confirm you are a suitable candidate.
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